Showing posts with label University. Show all posts
Showing posts with label University. Show all posts

Stresses of Unemployed Spouse Can Hurt Job Performance of Other Spouse, University of Colorado Study Finds


University of Colorado, February 21, 2011 -- Ignoring the stresses of an unemployed spouse's job search does not bode well for the employed spouse's job productivity or home life, says a University of Colorado Boulder professor.

Associate Professor Maw-Der Foo of CU-Boulder's Leeds School of Business studies employee workplace issues, including those related to interpersonal relationships.

Foo and lead author Professor Zhaoli Song of the National University of Singapore co-authored a paper titled "Unraveling the Stress Crossover Between the Unemployed and Their Spouses," which was published in last month's edition of the Journal of Applied Psychology.

In the study they examined daily stresses felt by married couples in which one spouse was employed and the other unemployed, and how that stress affected each spouse.

"One of the key findings in this study is that couples are better at sharing their burden than helping alleviate it," Foo said.

"If you feel bad at home there is going to be spillover at work where you will also feel lousy. Going into the study we thought that marital support might help alleviate the stress of unemployment on the family unit, but it didn't turn out to be the case."

One of the take-home messages from the study and others Foo has conducted on the workplace is that organizations need to be more sensitive and supportive when their employees have family members -- particularly a spouse -- who are unemployed.

"Organizations can implement family-friendly policies to help their employees fulfill their family roles, which in turn may increase the employee's productivity," he said.

However, in difficult economic times many organizations may elect to limit some services for their employees, such as couples counseling, due to their cost.

"Couples counseling may fall into the category of company cutbacks now because programs such as these usually don't affect the bottom line until some time down the road," Foo said. "Our findings call for more attention on the family as an integrated system in responding to the unemployment situation."

In the study, which took place in Shenyang, China, each couple turned in a daily report of their distresses. The researchers examined the interaction between the work life and family life of the employed and unemployed spouse. Since they had responses from both employed and unemployed people, they were able to compare them and draw conclusions.

"For example, the spouse experiencing job stress may reduce his or her marital support to their spouse, which then leads to more stress for the unemployed spouse, who then returns the favor and adds even more stress," Foo said.

One of the unique parts of the study, Foo said, is that they studied couples' interactions daily for two weeks. In particular, they looked at what is called the crossover effect, which refers to a situation when each spouse transmits and catches the stresses of the other.

"We looked at the unemployed person's activities and their distress, but we also looked at the work experience of the employed person and how that also spills over to the family relationship," he said.

Foo said more closely examining the stress and coping mechanisms among couples facing the problem of unemployment also may provide some practical insights to family counselors, psychotherapists and other practitioners who develop family-focused interventions to prevent the breakdown of relationships.

Marilyn Uy of the University of Victoria in Victoria, Canada, and Shuhua Sun of the National University of Singapore also contributed to the study.

Contact

Maw-Der Foo, Leeds School of Business, 303-735-5423

Greg Swenson, CU media relations, 303-492-3113

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Statins May Prevent Diabetic-Related Blindness, University of Georgia Study Suggests

Athens, Ga. – New University of Georgia research has found that a statin drug that is often known by the brand-name Lipitor may help prevent blindness in people with diabetes.

In a study using diabetic rats, lead author Azza El-Remessy, assistant professor in the University of Georgia College of Pharmacy, and her colleagues found that statins prevent free radicals in the retina from killing nerves important to maintaining vision. The results of the study are published in the March edition of the journal Diabetologia.

“The exciting part is that there are now treatment options that are proven to be safe that can be immediately translated to patients,” said El-Remessy.

Diabetic retinopathy is a leading cause of blindness in adults and is observed in most patients after 10 to 15 years of diabetes. There are no currently FDA-approved oral treatments for diabetic retinopathy, and surgical methods are expensive and painful, she added.

Uncontrolled diabetes and excessive glucose induces free radicals, which causes the eye to release a protein called pro-nerve growth factor, which normally matures into nerve growth factor (NGF) to protect the retinal nerves, explained El-Remessy. The free radicals that are generated by diabetes stop the maturation of proNGF into NGF, however, which leads to impaired neuronal function.

Using diabetic rats and isolated retinal cells cultured in high glucose, El-Remessy and colleagues found that oral treatment with the drug atorvastatin blocked the formation of free radicals in the retina, which restored proper levels of nerve growth factor and preserved neurons in the retina. “It removed the break on the pro-form nerve growth factor to develop into its mature form,” she said. The drug was orally administered to rats in doses proportional to levels given to human patients with cardiovascular problems.

In a related study, also in the March edition of the journal Diabetologia, El-Remessy and her colleagues found that epicathecin, a component of green tea, also prevented the adverse actions of proNGF in the retina. It does not affect the maturation of proNGF into NGF, explained El-Remessy, but regulated a receptor downstream that proNGF uses to send a signal to kill the neuron. Epicathechin prevents the death by inhibiting that receptor. “We are still getting the same result, that we are preventing neuronal death and restoring neuronal function, but just in a different way,” said El-Remessy.

The findings have implications not only for the eye, but also for other parts of the body where nerves are affected by diabetes, said El-Remessy. “Diabetic patients need to protect the nerves beyond vision,” she said. In future studies, she hopes to explore nerve functioning impaired by imbalance of proNGF in other parts of the body. “If proNGF accumulates in the eyes in diabetes, I can imagine that it accumulates in the nerve endings in the skin, in the foot, in the hand and in the brain… everywhere,” she said.

The study was supported by the American Heart Association Scientist Development Grant, a Juvenile Diabetes Research Foundation grant, the University of Georgia Research Foundation and a research grant from Pfizer International.

For more information on the UGA College of Pharmacy, see http://www.rx.uga.edu/.

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Oral Sex linked to Cancer Risk, Ohio State University Study Finds


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Oral Sex linked to Cancer Risk, Ohio State University Study Finds
2/22/2011

Physorg.com -- US scientists said Sunday there is strong evidence linking oral sex to cancer, and urged more study of how human papillomaviruses may be to blame for a rise in oral cancer among white men. In the United States, oral cancer due to HPV infection is now more common than oral cancer from tobacco use, which remains the leading cause of such cancers in the rest of the world.




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Bile Acids Link High-Fat Diet to Colon Cancer, University of Arizona Study

University of Arizona -- Bile acids could be the missing link between a high-fat, Western-style diet and colon cancer, University of Arizona researchers and their collaborators have discovered.

Seventeen out of 18 mice fed a standard diet topped off with bile acid developed colon tumors after eight or 10 months, the scientists report in the journal Archives of Toxicology.

"It has been known for a while that a diet rich in fat poses a risk for colon cancer," said Carol Bernstein, a research associate professor in the UA College of Medicine's department of cell biology and anatomy and lead author of the study.

"But until now, it wasn't known exactly why."

Her husband and co-author, Harris Bernstein, added: "Since the 1970s, people in the field have suspected that bile acids play a role, but they were thought to act merely as promoters, enhancing the cancer-causing effect of some other substance. Our findings show that bile acids themselves cause colon cancer."

Harris Bernstein is a professor of cell biology and anatomy.

Over the past 25 years, the Bernsteins have collected evidence suggesting that bile acids cause changes in the cells lining the walls of the colon, sending them down a path toward becoming cancerous.

"The bile acids cause damage to the cells' DNA, leading to mutations," explained Carol Bernstein. "Those mutations then cause changes in the activity of cancer-related genes."

Encouraged by their findings in mice, the Bernsteins are submitting a grant proposal to investigate the bile acids' role in cancer formation in more detail and how it compares to the situation in humans.

Bile acids are the body's own "dishwashing detergent." Produced by the liver and stored in the gall bladder, they are released into the intestinal tract to emulsify fat in food once it is passed on from the stomach to the intestine.

"Because it has been known for a while that bile acids such as deoxycholic acid, or DOC, play a key role in the formation of colon cancer, we wanted to know whether DOC alone is enough to trigger tumor formation," said Carol Bernstein.

To test their hypothesis, the scientists divided wild-type mice into four groups and fed them a standard diet for eight to 10 months, either with or without DOC added. DOC levels were assessed in the study animals' excrements. To make the experiments relevant to the human condition, the Bernsteins added DOC to the point where it showed up at the level found in previous studies in humans who were eating a high-fat diet.

"Obviously, there is still a difference in that mice are much smaller than humans," Carol Bernstein said, "and the exposure is much longer in humans. We get colon cancer mostly after the age of 50."

Of the 18 mice that received DOC in addition to the standard diet, all but one (94 percent) developed colon tumors, including 10 animals whose tumors had progressed to full-blown cancers. In contrast, no tumors were found in mice eating a standard diet without DOC.

Previous work done by the Bernsteins and other scientists showed that bile acids lead to the formation of additional reactive oxygen species, molecules that can damage cells. Also called free radicals, these molecules are normal by-products of metabolism. They are highly reactive, and if they encounter another molecule such as a protein or DNA, a chemical reaction occurs in which the target molecule is damaged.

The Bernsteins believe that DOC could increase reactive oxygen species to a level beyond the ability of a cell to repair all the damages they cause, ultimately leading to cancer.

"Even the average human cell that is not exposed to excess bile acids accrues about 10,000 damages over the course of a day through normal metabolism," Harris Bernstein said. The cells in our bodies depend on specialized enzymes to repair these average levels of damage."

Could bile acid cause colon cancer by ramping up the levels of the destructive free radicals? To address this question, the researchers fed mice with a standard diet containing bile acid, but also chlorogenic acid, an antioxidant found at high levels in blueberries, coffee and eggplant. Antioxidants are known to protect cells from damage by oxygen radicals.

Only 64 percent of mice in this category developed tumors, suggesting that chlorogenic acid offsets some of the cell damage inflicted by the bile acid.

Again, no colon tumors were found in any of the mice belonging to the control group fed with a standard diet plus antioxidant.

The Bernsteins are now beginning to measure the levels of excess DNA damage caused by increased DOC in the colons of mice. They are also starting to find reductions in DNA repair enzymes caused by addition of DOC to the diet.

Their new work could further explain the mechanism of how bile acids cause progression to cancer in the colon.

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Obesity Linked To Income, Education; Not Sprawl, University of Illinois Study


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Obesity Linked To Income, Education; Not Sprawl, University of Illinois Study
2/8/2011

Medical News Today -- Obesity is more prevalent in areas with lower educational attainment and certain ethnic profiles than in areas of suburban sprawl, according to researchers at the University of Illinois at Chicago. Researchers at UIC's Urban Transportation Center revisited their 2005 analysis of data from about 7 million northern Illinois drivers licenses, which found that body-mass index scores in most city neighborhoods differ little from those in the farthest outlying areas.




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Two Oral Cancer Drugs Effective in 'Steve Jobs' Disease, University of Texas MD Anderson Cancer Center Study


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Two Oral Cancer Drugs Effective in 'Steve Jobs' Disease, University of Texas MD Anderson Cancer Center Study
2/10/2011

MedPageToday -- Two small-molecule kinase inhibitors appear to be effective at extending progression-free survival in pancreatic neuroendocrine tumors, researchers say. In patients with advanced disease enrolled in phase III trials, both everolimus, an mTOR inhibitor, and sunitinib, a tyrosine kinase inhibitor, each halted disease progression significantly longer than placebo, according to two studies in the Feb. 10 issue of the New England Journal of Medicine.




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Calcium May Provoke Preterm Labor, Yale University Study

New Haven, Conn. — Researchers at Yale School of Medicine have found that excessive formation of calcium crystal deposits in the amniotic fluid may be a reason why some pregnant women suffer preterm premature rupture of the membranes (PPROM) leading to preterm delivery.

This is a key breakthrough in solving the mystery of preterm birth, a leading cause of death and permanent disability in newborns. The findings will be presented in an abstract at the Society for Maternal-Fetal Medicine Scientific Sessions on February 10 in San Francisco, California.

Researchers know that infection, maternal stress and placental bleeding can trigger some preterm deliveries, but the cause of many other preterm deliveries remains unknown. In these cases, women experience early contractions, cervical dilation and a torn amniotic sac.

A team of researchers in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, including first author Lydia Shook and her mentor Irina Buhimschi, M.D., investigated the idea that calcification-excessive buildup of calcium-of the fetal membranes may lead to PPROM and preterm birth. "We noticed that in many women, analysis of the proteins in their amniotic fluid did not show signs of inflammation, and we could not find any cause for their preterm birth," said Shook, a Yale medical student. "We took a fresh look for what was causing breakdown of the membranes, which can lead to lost elasticity, integrity and eventually rupture."

Scientists know that calcifying nanoparticles are involved in many degenerative conditions including arthritis and atherosclerosis. "These mineral-protein complexes can disrupt normal cellular processes and cause cell death," Shook said. "We wondered whether they could also be responsible for damage to the fetal membranes in pregnant women."

Shook and her co-authors used a stain to look for calcium deposits in placental and fetal membrane tissue from patients with PPROM and preterm birth, as well as full-term deliveries. They used a sterile culture technique to determine whether amniotic fluid can form nanoparticles. They then exposed fetal membranes to the cultured nanoparticles to determine their ability to induce cell dysfunction, damage and cell death.

The team found evidence of calcification of fetal membranes collected from preterm deliveries. Fetuin, one of the major proteins involved in nanoparticle formation, was found in these deposits. Levels of fetuin in amniotic fluid were lower in women who delivered with PPROM compared to those who delivered early with intact membranes.

"This preliminary evidence suggests that amniotic fluid has the potential to form nanoparticles and deposit them in the fetal membranes," said Shook. "Low fetuin may be a biomarker for women at risk of PPROM. The goal of this research is to identify women at risk of developing this condition early in their pregnancy and to intervene with targeted therapy."

Other Yale authors on the abstract include Catalin Buhimschi, Antonette Dulay, Guomao Zhao, Unzila Ali, Christina Han, Katherine Campbell and Erika Werner.

PRESS CONTACT: Karen N. Peart 203-432-1326

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Can Pomegranate Pills Fight Prostate Cancer? - Johns Hopkins University School of Medicine Study


Can Pomegranate Pills Fight Prostate Cancer? - Johns Hopkins University School of Medicine Study
2/18/2011

WebMD -- Feb. 17, 2011 (Orlando, Fla.) -- Taking a pomegranate pill a day may help slow the progression of prostate cancer, preliminary research suggests. The study is the latest to demonstrate pomegranate's promising antitumor effects, says study head Michael Carducci, MD, professor of oncology and urology at Johns Hopkins Medical Institutes.

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Breast Cancer Surgery to Remove Extra Lymph Nodes Doesn't Help Survival, Emory University Study


Breast Cancer Surgery to Remove Extra Lymph Nodes Doesn't Help Survival, Emory University Study
2/9/2011
WebMD -- Feb. 8, 2011 -- Many women being treated for early breast cancer can keep the lymph nodes under their arms without fear that it will hurt their chances of survival or the increase the odds that their cancer will return, experts say. A new study shows that about 92% of women with early-stage breast cancers that have spread to a nearby lymph node who have lumpectomies and radiation to treat their tumors will be alive five years later, whether or not they have multiple lymph nodes removed from under their arms, a procedure called an axillary lymph node dissection.




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Waking up is Hard to Do: Scientists Identify a Gene Important for the Daily Rhythms of the Sleep-Wake Cycle, Northwestern University Study

EVANSTON, Ill. --- Northwestern University scientists have discovered a new mechanism in the core gears of the circadian clock. They found the loss of a certain gene, dubbed “twenty-four,” messes up the rhythm of the common fruit fly’s sleep-wake cycle, making it harder for the flies to awaken.

The circadian clock drives, among other things, when an organism wakes up and when it sleeps. While the Northwestern study was done using the fly Drosophila melanogaster, the findings have implications for humans.

The research will be published Feb. 17 in the journal Nature.

“The function of a clock is to tell your system to be prepared, that the sun is rising, and it’s time to get up,” said Ravi Allada, M.D., who led the research at Northwestern. “The flies without the twenty-four gene did not become much more active before dawn. The equivalent in humans would be someone who has trouble getting out of bed in the morning.”

Allada is professor of neurobiology and physiology in the Weinberg College of Arts and Sciences and associate director for the Center for Sleep and Circadian Biology.

Period (per) is a gene in fruit flies that encodes a protein, called PER, which regulates circadian rhythm. Allada and his colleagues found that twenty-four is critically important to producing this key clock protein. When twenty-four is not present very little PER protein is found in the neurons of the brain, and the fly’s sleep-wake rhythm is disturbed.

It seems it was fate that the gene Allada and his team pinpointed would be important in regulating the 24-hour sleep-wake cycle. The gene’s generic name is CG4857, and the numbers add up to 24, earning it the twenty-four nickname. (The fruit fly’s genome was sequenced in 2000, but until now the function of this gene was unknown.)

The known core mechanisms of the circadian clock, both in flies and humans, involve the process of transcription, where RNA is produced from DNA. A portion of the control system called a transcriptional feedback loop also is important. (The word circadian comes from the Latin phrase “circa diem,” meaning “about a day.”)

In trying to identify new clock components, the researchers identified a new player in the system, the gene twenty-four. Instead of operating in the process of transcription, they found twenty-four operates in the process of translation: translating proteins from RNA.

Twenty-four appears to be a protein that promotes translation of period RNA to protein. “This really defines a new mechanism by which circadian clocks are functioning,” Allada said. “We found that twenty-four has a really strong and critical role in translating a key clock protein. Translation really wasn’t appreciated before as having such an important role in the process.”

The researchers believe it is likely that a mechanism similar to that described for the fly gene twenty-four will be evolutionarily conserved and found in humans.

Allada and his Northwestern team worked with scientists at the Korea Advanced Institute of Science and Technology (KAIST). Using a Drosophila library at KAIST, the researchers first screened the behavior of 4,000 different flies looking for flies whose sleep-wake cycles were awry. (Each fly had a different overexpressed gene and thus different behavior.) The fly with the most dramatic change was one with a longer cycle than normal, 26 hours instead of 24.

The overexpressed gene in this fly was CG4857. The researchers next removed, or knocked out, this gene in the flies. These flies had very poor sleep-wake rhythm and would sleep and wake at all times of day. The researchers found very little of the critical PER protein in the brain neurons despite the fact that per RNA is likely produced in the neurons. Without twenty-four the RNA was not translated into the PER protein, leading to dysfunction.

The National Institutes of Health and the National Research Foundation of Korea supported the research.

The paper is titled “The Novel Gene Twenty-four Defines a Critical Translational Step in the Drosophila Clock.” In addition to Allada, other authors of the paper Chunghun Lim and Valerie L. Kilman, from Northwestern; Jongbin Lee, Changtaek Choi, Juwon Kim and Joonho Choe, from Korea Advanced Institute of Science and Technology, Korea; and Sung Mi Park and Sung Key Jang, from Pohang University of Science and Technology, Korea. Megan Fellman is the science and engineering editor. Contact her at fellman@northwestern.edu

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Pollution with Antibiotics Leads to Resistant Bacteria, University of Gothenburg and Collaborators Study Reveals

University of Gothenburg -- Many of the substances in our most common medicines are manufactured in India. Some of these factories release huge quantities of drugs to the environment. Swedish scientists now show that bacteria in polluted rivers become resistant to a range of antibiotics. International experts fear that this may contribute to the development of untreatable infectious diseases world-wide.

Using a novel method, based on large-scale DNA sequencing, the Swedish scientists show that bacteria residing in Indian rivers are full of resistance genes, protecting them from otherwise effective antibiotics.

"Since we buy medicines from India, we share moral responsibility to reduce the pollution,"says Joakim Larsson, associate professor at the Sahlgrenska Academy, University of Gothenburg, one of the scientists behind the study.

"If the pollution contributes to resistance development in clinically important bacteria, it becomes our problem also in a very direct way," he says.

"We have combined large-scale DNA sequencing with novel ways to analyze data to be able to search for thousands of different antibiotic resistance genes in parallel," says Erik Kristiansson, assistant professor at Chalmers University of Technology.

"Such an approach may become useful also in hospitals in the future," he points out.

Several international experts, interviewed by the journal Nature, describe the results as worrying.

"Even if the bacteria found are not dangerous to humans or other animals in the area, they may transfer their resistance genes to bacteria that are," says Dave Ussery, a microbiologist at the Technical University of Denmark

David Graham at Newcastle University, UK, describes the Indian site. "In a way, it's sort of like a beaker experiment that tests the worst-case scenario, only this is in a natural system."

Björn Olsen, an infectious-disease specialist at Uppsala University in Sweden compares the resistance with volcano-ash. "The cloud is going to drop down somewhere else, not just around the sewage plant."

The study was carried out at the Sahlgrenska Academy, University of Gothenburg in collaboration with Chalmers University of Technology and Umeå University, Sweden

For more information please contact:

Associate professor Joakim Larsson, phone: +46 31 786 3589, +46 709 621068, e-mail: joakim.larsson@fysiologi.gu.se: website: http://www.neurophys.gu.se/sektioner/fysiologi/endo/joakim_larsson/

Assistant Professor Erik Kristiansson, phone: +46 31 772 3558, + 46 705 259751, e-mail: erik.kristiansson@chalmers.se

Journal: PLoS ONE Title of article: Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements

Authors: Erik Kristiansson, Jerker Fick, Anders Janzon, Roman Grabic, Carolin Rutgersson, Birgitta Weijdegård, Hanna Söderström, D G Joakim Larsson.

Read the article: http://dx.plos.org/10.1371/journal.pone.0017038

Comments from international experts: http://www.nature.com/news/2011/110216/full/news.2011.46.html

BY: Ulrika Lundin +46 31 786 6705, +46 70 775 8851

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Pessimists' Brains May Be Wired that Way, University of Michigan Study Published in

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Blood Pressure Drug Could Harm Stroke Patients, University of Oslo Study Finds

University of Oslo -- A drug that lowers blood pressure could harm patients if given after a stroke, says a new study. A Norwegian study of 2,000 stroke patients, who had high blood pressure, found that more of those treated with the drug candesartan suffered from kidney failure than those who were not given it.



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Dual Vaccine Strategy Protects Against Avian Flu, Saint Louis University School of Medicine Finds

Saint Louis University -- ST. LOUIS -- A stockpiled vaccine designed to fight a strain of avian flu that circulated in 2004 can be combined with a vaccine that matches the current strain of bird flu to protect against a potential pandemic, researchers from Saint Louis University's Center for Vaccine Development have found.

The findings suggest public health officials can get a jump on fighting a pandemic caused by avian flu virus because they won't have to wait for a vaccine that exactly matches the current strain of bird flu to be manufactured. They can begin immunizing against the bird flu by giving an injection of a vaccine made from a related, yet mismatched strain of flu to prime the body for a second shot of a vaccine that matches the current strain.

"A cornerstone of pandemic planning is the development of effective vaccines against avian influenza infection," said Robert Belshe, M.D., director of the Center for Vaccine Development at Saint Louis University and the lead author of the paper.

"The results of the present study confirm the usefulness of vaccination with an H5 strain that isn't the current dominant strain."

Avian flu -- or H5N1 -- is a highly infectious and deadly virus that circulates in birds and has the potential to genetically mutate and jump between species to infect humans. Because people lack immunity to the virus, public health officials are concerned that the virus can spread quickly to become a pandemic outbreak.

In anticipation of a bird flu pandemic, in 2004 the U.S. government stockpiled 20 million doses of vaccine against the "Vietnam" strain of avian influenza, which then was the dominant strain of the virus. But the avian flu changes quickly and since then, a different strain of bird flu, known as the "Indonesia" strain, has replaced the Vietnam strain as the prominent circulating avian flu.

Researchers studied both the vaccine against the Vietnam strain and an investigational vaccine designed to protect against the Indonesia strain in 491 healthy adults. They measured the body's immune response to different combinations of the two avian flu vaccines. They also looked at how long to wait between giving the first and second doses of vaccine.

They found that two doses of vaccine are needed to provide protection against the avian flu. Giving the stockpiled Vietnam avian flu vaccine as the first dose primed the body's system so that a follow up dose of the investigational Indonesia avian flu vaccine triggered a heighten immune response. The immune response to both strains of avian influenza became more robust as the injections of vaccine were spaced further apart.

"The longer 180-day interval between priming and boosting vaccine doses gave the best antibody responses, although in a fast-moving pandemic, this is unlikely to be an option," Belshe said.

"The most surprising thing we discovered was the value of time. It's incredible how much stronger response you get at six months. There's something going on there that we know nothing about and is a very interesting area for future research."

Other areas of future of research include studying the vaccines in children and adults and examining the use of adjuvants, substances that stimulate the immune response to produce more antibodies so less vaccine is needed, Belshe added.

Public health officials might consider immunizing those who are at risk of serious side effects from influenza with the stockpiled avian flu vaccine, he said.

The vaccine could prime the body's immune system to mount a defense if the person is exposed to the avian flu virus and could be a powerful weapon in the fight against a pandemic, Belshe said.

Funded by the National Institute of Allergy and Infectious Diseases (NIAID), which is part of the National Institutes of Health, the research appears in the March issue of the Journal of Infectious Diseases.

On the forefront of research in fighting and preventing infectious diseases, Saint Louis University has received federal funding as a Vaccine Treatment and Evaluation Unit for two decades. One of eight NIAID-funded vaccine research centers, Saint Louis University evaluates new and improved vaccines for diseases such as influenza and novel ways of delivering them.

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Stunting Tall Girls' Growth May Impact Fertility, Erasmus University Medical Center Study


MSN -- Years ago, tall girls often received hormones to stunt their growth — and now as adults they seem to have more difficulty becoming pregnant than women who weren't treated, a new Dutch study reveals. The study is the second to show that stunting girls' growth, which was widely done in Europe, Australia, and the United States starting in the 1950's, may have long-term consequences on their reproductive systems.




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Expectations Can Cancel Out Benefit of Pain Drugs, Oxford University Study

who don't believe their pain medicine will work can actually reduce or even cancel out the effectiveness of the drug, and images of their brains show how they are doing it, scientists said on Wednesday. Researchers from Britain and Germany used brain scans to map how a person's feelings and past experiences can influence the effectiveness of medicines, and found that a powerful painkilling drug with a true biological effect can appear not to be working if a patient has been primed to expect it to fail.




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Inhaled Epinephrine Confirmed Quick, Effective For Croup, University of Calgary Study


Medical News Today -- For more than 30 years, pediatricians have treated children who have croup with inhaled epinephrine to relieve their symptoms quickly. Now, a new review confirms the value of this approach to treat this common respiratory illness, which sometimes turns serious and - in rare instances - can prove fatal.




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Alcohol Disrupts Women's Sleep More Than Men's: University of Michigan Study


Alcohol Disrupts Women's Sleep More Than Men's: University of Michigan Study
2/16/2011

TUESDAY, Feb. 15 (HealthDay News) -- Alcohol appears to cause more sleep problems in women than in men, a new study found. It's long been known that alcohol can deepen sleep during the early part of the night but disrupt sleep later in the night, something called the "rebound effect." But there's been little research into how alcohol's effects on sleep may differ in women and men.

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Discovery Of New Gene Test For Inherited Neuromuscular Disorder, University of Newcastle Study

Newcastle University -- Newcastle University scientists have identified a new gene which will allow rapid diagnosis and earlier treatment of a debilitating neuromuscular condition.
The gene, GFPT1, is crucial in causing a variation of Congenital Myasthenic Syndrome (CMS) which gained media attention recently with the plight of baby RB, who was at the centre of a “right-to-life” legal dispute.
CMS is a rare genetic condition affecting the way signals travel between the brain and muscles which can cause paralysis and in some cases death. It affects one in every 500,000 births and the severity of the condition varies, depending on where the fault lies in the complex signals between the nerves and the muscles.
The variation of CMS identified by the team of international researchers, GFPT1, tends to develop in the first ten years of life with patients losing muscle strength and control in their hips and shoulders or arms and legs.
“The identification of this gene means that doctors can order genetic analysis and confirm the condition allowing earlier treatment with cholinesterase inhibitors,” explained Professor Hanns Lochmüller of the Institute of Human Genetics at Newcastle University.
“This offers an effective therapy which can be taken through life,” he added.
The research also highlighted a new area to explore for future treatments as GFPT1 is involved in initiating the metabolism of amino sugar.
The international team, headed up by Dr. Jan Senderek from the University of Aachen in Germany and by Dr Juliane Müller from Newcastle University, analysed the genes of 13 families affected by the condition.
Academic paper: Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect
Published in: AJHG - The American Journal of Human Genetics
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